Application of hyperspectral camera in drug composition analysis

Application of hyperspectral camera in drug composition analysis

1、 Main applications

Drug identification and classification:

Hyperspectral imaging technology can form a data cube containing two-dimensional spatial information and one-dimensional spectral information of drugs by collecting image data of drugs in multiple narrow bands. This enables hyperspectral cameras to identify different types of drugs, even if they are visually very similar.
Active pharmaceutical ingredient (API) measurement:

By combining chemometric methods, hyperspectral data can be analyzed to extract information related to the chemical composition of drugs. This includes measuring the content and distribution of active pharmaceutical ingredients to ensure the quality and consistency of the drug.

Hyperspectral imaging can cover the entire material flow online with nearly 100% accuracy, monitor the drug manufacturing process in real-time, and help manufacturers ensure the quality, purity, and improvement of their manufacturing processes.
Drug defect and impurity detection:

Hyperspectral cameras can detect defects and impurities in drugs without damage and quickly, which is difficult to achieve with traditional detection methods. This non-destructive testing method is crucial for ensuring drug safety.
Real time product flow inspection:

Hyperspectral imaging technology can inspect 100% of the product flow in real time, ensuring that every step of the drug production line meets quality standards.
Specific application scenarios:

Hyperspectral imaging technology has been successfully applied in the identification of honeysuckle and mountain silver flowers. This technology can quickly, non destructively, and accurately identify these two Chinese medicinal materials that have similar appearance but significant differences in quality and value.

2、 Practical application

1. Experimental purpose

Analyze the components of the drug

这是客户给我们寄来的样品

2. List of experimental testing instruments

3. Experimental content

(1) Classify and detect 8 different components of drugs in the 400-1000nm and 900-1700nm wavelength bands

(2) The testing process is shown in the figure. Place 8 types of drugs on the testing platform for testing, and observe the reflectance curve of the samples

4. Experimental results

The results captured at 900-1700nm show significant spectral differences between different samples

Software screenshot 4:

5. Conclusion

Based on the above 8 sets of sampling test results, it can be seen that the ingredients of drug 1.3.4 are extremely similar, with little difference in composition. After comparing the data with the customer, they stated that sample 1.3.4 is the same ingredient and consistent with our test results. For other types of drugs, the absorption and reflection characteristics of different bands can be combined to conduct deeper ingredient identification and recognition

3、Application of hyperspectral camera in drug composition analysis

Overall, hyperspectral cameras have significant advantages in drug composition analysis, including non-destructive testing, high precision, and real-time monitoring. These characteristics make hyperspectral imaging technology play an increasingly important role in drug production and quality control processes. With the continuous advancement of technology, the application of hyperspectral cameras in the pharmaceutical field will become more extensive and in-depth in the future.